help with physiology please?3. Suppose a woman with a family history of polycystic kidney disease develops proteinuria. She has elevated blood creatinine levels and a reduced inulin clearance. What might these lab results indicate? Explain.
Posted by Chardog83
Creatine levels in the blood and urine are used to calculate the creatine clearance (CrCL), which reflects the GFR (glomerular filtration rate). The GFR is clinically important because it is a measurement of renal function. This patient has kidney disease, hence decreased renal function, and consequently a decreased GFR. This means less creatine will be excreted in the 'urine,' and hence 'blood' levels will rise.
Insulin is eliminated renally, and since the patient has decreased renal function, less insulin will be cleared in the urine, and consequently blood levels will rise. (this is the same reasoning for the creatine levels rising as well)
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