What are the causes of acute tubular necrosis when considering Acute Kidney Failure?All of these things can cause AKF, but which ones cause ATN specifically?
Shock
Pump failure
Toxins (eg. gentamicin)
Bilateral RAS
Embolism
Thrombus
Vasculitis
Glomerular disease (nephritic/nephrotic)
Interstitial nephritis
Tubulitis from drugs (methicillin) and infection
Thanks for your help
Posted by Samual Bobster Man
That's a very useless list you have there, so I'm going to ignore it and just answer your question instead.
There are three TYPES of renal failure: prerenal, renal, and postrenal. Bare with me as I explain each, and then I'll answer you're question.
Renal renal failure (the middle one from the group above) means your kidneys don't work properly because the cells in your tubials are f*cked. Once these cells are f*cked, you have renal failure, simple as that. This Is basically what acute tubular necrosis is (eg. acute means it happend quickly; tubular refers to where the cells are – they are located in your renal tubuals; and necrosis means dead cells).
Pre-renal failure means that your kidney cells are still perfectly fine, but your kidneys are unable to do their job because you're body is failing to produce enough pressure to force the liquid from your blood stream into your kidneys. The kidneys job is to filter this liquid, but if they kidneys don't receive this liquid because something else goes wrong, then you're kidneys wont be able to do their job even though all your kidney cells are perfectly healthy.
Don't worry about what post renal failure is – it doesn't matter.
Now here is the answer to your question!
You're tubular cells, like all the other cells in your body, need nutrients such as oxygen. Usually they get this from the liquid which they are filtering. SO imagine you have pre-renal failure. Remember I said that in pre-renal failure your kidney cells were still healthy? Well that's true, but it wont stay true for long because if you stay in pre-renal failure for too long those cells with die from lack of nutrients and THIS is called "acute tubular necrosis".
Posted by sunflowers
Necrosis is cell death and gangrene, so anything that can kill cells can cause necrosis.
Toxins and toxic drugs, lack of blood flow to the cells, any disease process which disturbs blood flow to the cells or causes a buildup of waste products that poison the cells. So I would go with all of the above as a starter with many more things possible also.Also probably diabetes and resulting cell and tissue problems from high blood glucose levels and from infections that love to feed on high blood sugar. Also probably untreated high blood pressure.
Have to admit I would have to google search bilateral RAS though.
Orignal From: Kidney Disease: What are the causes of acute tubular necrosis when considering Acute Kidney Failure?
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